Covid-19 Vaccine

For the 2025-2026 El Dorado TrueCare Pharmacy will be offering 2 types of Covid-19 Vaccine: mNEXSPIKE AND SPIKEVAX by Moderna.

	mNEXSPIKE	SPIKEVAX
Target	Codes for only two parts of the spike protein; more targeted	Codes for the entire spike protein
Dose Size	A smaller, more focused dose of 10mcg	A larger dose, 50mcg for patients 12 years +
Relative Efficacy	In a clinical trial, mNEXSPIKE showed 9.3% greater relative efficacy than SPIKEVAX in adults. This increased to 13.5% in those over 65.	The original vaccine proved highly effective in preventing severe COVID-19.
Approved Population	Primarily approved for high-risk individuals and seniors: • Adults 65 and older • People aged 12–64 with underlying health conditions.	Approved for a much wider population: • Adults 65 and older • People aged 6 months to 64 with underlying health conditions.
Side Effects	Lower rates of local adverse reactions such as pain, swelling and redness at the injection site. Systemic adverse reactions such as fatigue, headache, chills and fever were comparable to SPIKEVAX	Higher rates of local adverse reactions. Systemic adverse reactions were similar to mNEXSPIKE

* If you are between the ages of 12-64 years of age you will need to attest to at least one underlying condition as defined by the CDC.

Click HERE for Up-to-Date Covid-19 Vaccination Recommendations!

Underlying Conditions and Higher Risk for Severe COVID-19

For patients 12-64 you will be asked to attest to one of the following conditions.

Asthma
Cancer
Cerebrovascular disease
Chronic kidney disease
Chronic lung diseases, limited to bronchiectasis, COPD (Chronic Obstructive Pulmonary Disease), interstitial lung disease, pulmonary embolism, pulmonary hypertension
Chronic liver diseases, limited to cirrhosis, non-alcoholic fatty liver disease, alcoholic liver disease, autoimmune hepatitis
Cystic fibrosis
Diabetes mellitus, type 1 and type 2
Disabilities, including Down syndrome (complete list included here)
Epilepsy
Heart conditions (such as heart failure, coronary artery disease, or cardiomyopathies)
Hemophilia
HIV (human immunodeficiency virus)
Mental health conditions, limited to mood disorders (including depression), schizophrenia spectrum disorders
Neurologic conditions, limited to dementia and Parkinson’s Disease
Overweight (BMI >30 )
Physical inactivity
Pregnancy or recent pregnancy
Primary immunodeficiencies
Sickle cell disease
Smoking, current or former
Solid organ or blood stem cell transplantation
Tuberculosis
Use of corticosteroids or other immunosuppressive medications